Changes in young women’s contraceptive use in the Netherlands: findings from three sex under the age of 25 surveys

Prevention of unintended pregnancy among adolescents and young adults under 25 years is pivotal from an individual as well as societal perspective. In the USA, the use of long-acting reversible contraceptive (LARC) has been shown to increase, with no or little change in the use of short-acting reversible contraceptive (SARC). We assessed trends in no contraceptive, SARC, and LARC use by young women, aged between 12 and 25 years, and differences in trends within demographic groups (age, religion, ethnic background, and educational level) among these young women in the Netherlands. Data of sexually active young women aged 12–25 years from three cross-sectional representative surveys, 2005, 2012, and 2017, were used for this study. In total, 11,229 Dutch young women were included with a median age of 20 years (interquartile range 18–23 years). Overall, the proportion of young women using SARC decreased significantly between 2005 and 2017 from 88 to 76%. LARC use increased significantly between 2005 and 2017 from 3 to 16%. These trends varied by religious groups and educational level, emphasizing potential for tailored preventative measures for these groups. A shift towards LARC use might eventually lead to a further decrease in unwanted pregnancy and potentially abortion because of the lower risk of user errors.


Introduction
In Western countries, contraceptives are widely used. According to estimates of the United Nations, approximately 49% of women living in Europe aged 15-49 years used modern contraceptives in 2019 (United Nations, 2019). Modern methods of contraception include female and male sterilization, oral hormonal pill, vaginal ring, the intrauterine device, male and female condom, injectable, implant, vaginal barrier method, standard day method, lactational amenorrhea method, and emergency contraception. Traditional methods of contraception include (periodic) abstinence, the withdrawal method, the rhythm method, douching, and folk methods (Cahill et al., 2018). As shown by the various modern contraceptive methods, choice of contraceptive method is diverse. Which contraceptive method is chosen is a personal choice, but often influenced by co-factors, like finances, accessibility, and availability (Deitch & Stark, 2019;Ponce de Leon et al., 2019;Ugaz, Chatterji, Gribble, & Mitchell, 2015). Short-acting reversible contraceptives (SARCs) like oral contraception pills and the vaginal ring, tend to be used more than long-acting reversible contraceptives (LARCs) like intrauterine devices (Daniels, Daugherty, Jones, & Mosher, 2015;Darroch & Singh, 2013;Hopkins et al., 2018;Ponce de Leon et al., 2019;Ugaz et al., 2015). However, LARCs have some advantages compared to SARC, specifically in effectiveness, safety, cost-effectiveness, and once inserted they are independent of user compliance or correct usage (Shoupe, 2016;Stoddard, McNicholas, & Peipert, 2011;Walsh et al., 2004). Therefore, the 12month typical-use contraceptive failure rates are 4 to 9 times higher for SARC than for LARC (Polis et al., 2016).
Contraceptive use in the Netherlands is high. In 2017, 92% of young men and 94% of young women aged 12 to 25 years reported to have used any contraceptive during their first intercourse (De Graaf, Verbeek, Van den Borne, & Meijer, 2018). Trends in the Netherlands show a stable prevalence of modern contraceptive use between 65 and 70% among women aged 15 to 49 years since approximately 1980 (United Nations, 2019). In a European survey in 20 European countries, the Netherlands appeared to have the third highest level of contraceptive use at last intercourse among 15-year olds (Inchley et al., 2016). The high contraceptive use in the Netherlands contributes to teenage pregnancy and abortion rates that are among the lowest in the world (Sedgh, Finer, Bankole, Eilers, & Singh, 2015). However, the vast majority of Dutch women uses oral contraceptives, a method with relatively high contraceptive failure rates. Therefore, a shift towards LARC use could also lower unintended pregnancy rates within this country. Prevention of unintended pregnancy is pivotal from an individual as well as societal perspective (Davtyan, 2000). For example, women with unplanned pregnancy engage fewer in healthy practices and experience more depressive symptoms during pregnancy (Karaçam & Ançel, 2009;Yanikkerem, Ay, & Piro, 2013).
As shown in previous studies, trends in SARC and LARC use are not equally large in all demographic groups (i.e., based on age, religion, educational level, ethnicity, or partner status). In general, LARC use was found to be more prevalent among women over 19 years (Daniels et al., 2015;Moreau et al., 2013;Ponce de Leon et al., 2019), more educated women (Ihongbe & Masho, 2017;Kramer, Higgins, Godecker, & Ehrenthal, 2018;Ponce de Leon et al., 2019) and women in a steady relationship (Moreau et al., 2013;Walsh-Buhi & Helmy, 2018). General contraceptive use was found to be lower among religious young women (Moreau et al., 2013), but LARC use per se does not seem to be related to religion (Kramer et al., 2018). In the USA, black women were found to use LARC less often (Kramer et al., 2018) or similar (Ihongbe & Masho, 2017) compared to white and Hispanic women. It is not clear, however, how these ethnic groups compare to those in the Netherlands, although the higher prevalence of repeat abortions among women from Moroccan, Turkish, Surinamese or Antillean descent suggests that their contraceptive choices might be less effective (Picavet, Goenee & Wijsen, 2013). However, all these differences in usage do not inform us about differences in trends in contraceptive methods. For example, Kavanaugh and Jerman (2018) found that IUD use was related to several demographic variables, but that the increase in IUD was similar in all groups regardless of these characteristics. Demographic differences in trends over time are rarely studied and if they are, trends were generally similar in different demographic groups (Adedini et al., 2019;Kavanaugh & Jerman, 2018).
Research into recent trends in modern contraceptive use in the Netherlands is lacking. We assessed trends in types of modern contraceptives used among young women, aged 12 to 25 years, in the Netherlands who at least once experienced sexual intercourse (penile-vaginal penetration). In order to tailor specific and targeted preventive efforts to demographic groups that lag behind in the shift towards LARC methods, insight in differences in trends in contraceptive use is important. Therefore, the second purpose of this paper is to assess differences in trends of no contraceptive use, SARC, and LARC use by demographic factors among young women in the Netherlands.

Sample
In the Netherlands, a national population survey into the sexual health of young people aged 12 to 25 years has been conducted in 2005, 2012, and 2017, titled "Sex under the age of 25." Data for these studies were collected from young people aged 12 to 25 years using two methods: (1) through randomly selected schools (aged 12-17 years) and (2) from a random sample drawn from the municipal population registers (aged 17-25 years). Recruitment of schools was based on the distribution of students over school year and school type that matched with the distribution among all students in Dutch secondary education. Within every school, three to four classes were randomly selected, depending on the size of the school. If a selected school was unable or unwilling to participate, a comparable school in the same region was selected. Participants recruited via schools completed this questionnaire during a regular class period, whereas participants recruited via the municipal population registers received a letter of invitation (and up to two reminders among non-responders) and completed the questionnaire at home. The method of data collection was described in more detail in previous publications (De Graaf et al., 2018;De Graaf, Vanwesenbeeck, & Meijer, 2014;De Graaf, Vanwesenbeeck, Meijer, Woertman, & Meeus, 2009).
In total, 29 schools participated in 2005, 43 schools in 2012, and 106 schools in 2017.
Concerning the recruitment from municipal population registers, in 2005 12,460, in 2012 33,000, and in 2017 17,368 invitation letters were send. Non-responders were reminded twice. In every year of data collection, but especially in 2017, municipal health services recruited extra participants in their own region. Weighting techniques were applied to all three datasets, to correct for selective non-response as well as for oversampling in some regions. Therefore, each sample was representative for the Dutch population aged 12-25 in that particular year with regard to age, educational level, and ethnic background. The total number of young people who completed the questionnaire was 4820 in 2005, 7841 in 2012, and 20,840 in 2017.

Measures
All participants completed the same online questionnaire including questions on a broad range of sexual health themes. In the current study, the following measures were included in the analyses: age, which was measured in or recoded to whole years. Educational level. Participants were classified as "less educated" if they were enrolled in prevocational or secondary vocational education or if they were no longer enrolled in school and had completed pre-university education at most. Participants were classified as "more educated" if they were enrolled in general secondary, pre-university, higher professional or university education or if they were higher professional or university graduates.
Religion was a combined measure of two questions: (1) whether religion was important to the participant with (2) self-reported religion. This combined measure was recoded into five categories (1 = not religious; 2 = Christian, some importance; 3 = Christian, very important; 4 = Muslim; 5 = Other). Because of the very few Muslim participants who attached merely some importance to religion, we were not able to distinguish levels of importance within this group.
Ethnicity was based on country of birth of the participant and of his or her parents. If a participant was born outside of the Netherlands, the country of birth was leading in determining ethnicity; otherwise, the country of birth of the mother was leading, unless the mother was born in the Netherlands. In that case, country of birth of the father was leading.
Partnership status shows whether participants were in a relationship when they completed the questionnaire.
Contraceptive use, the outcome measure, was assessed in the survey with two questions "Do you currently use contraceptives?", and if yes, "What contraceptive method are you currently using?". Young women could choose between no contraceptive use, oral contraceptives, condoms, oral contraceptives and condoms, injectable contraceptives, contraceptive patch, contraceptive ring, contraceptive implant, intrauterine device, and other contraceptive. In analyses, this outcome measure was categorized into the following: no contraceptive use, short-acting contraceptive use (including condoms, oral-, injectable-, vaginal ring-, and patch contraceptives), and long-acting contraceptive use (including contraceptive implants and intrauterine devices).
Due to routing in the questionnaire, this question was only asked to young women with experience of sexual intercourse (penile-vaginal penetration). Young women who did not use any contraceptive and indicated that the reason for this was a lack of current sexual activity (with males) were excluded from analyses, since there is no risk for unintended pregnancy.

Statistical analyses
The different years of data collection were compared on demographics using chisquared tests and type of contraception was compared by Fisher-exact tests due to limited use of some contraception methods. Trends over time in types of contraceptive methods used (no contraceptive use, SARC use, and LARC use) were assessed for the total sample and for the separate demographic groups, using non-parametric test for trend based on the Wilcoxon method (Cuzick, 1985).
Since demographic factors included in this analysis might not be independent, univariable and multivariable multinomial logistic regression was performed to assess whether year of inclusion is associated with type of contraceptive used while controlling for demographic factors.
To assess if use of contraceptive method differed between groups within a demographic variable over time, multivariable multinomial logistic regression, including a demographic variable and inclusion year, was performed in which interaction was tested between the demographic variable and inclusion year. Due to power limitations, specifically in some religious and ethnic groups, a multivariable multinomial logistic regression including all demographic variables as well as interaction of one of the demographic variables and inclusion year could not be performed.
A significance level of 0.01 was used to compensate for the large sample size and multiple testing. Based on the increased power required for interaction testing and limited number of interaction tests performed, we used a significance level of 0.05 for interaction testing. Weighting techniques were applied to all analyses in order to ensure representativeness of the Dutch population. All analyses were performed using the SPSS (IBM Corp. Released 2018. IBM SPSS Statistics for Windows, version 25.0. Armonk, NY: IBM Corp.) and R Statistical Software (version 3.6.1).

Study participation
Over the years, in total, 11,668 Dutch young women aged 12 to 25 years who had at least once experienced sexual intercourse (penile-vaginal penetration) participated in the "Sex under the age of 25" studies. Within this group, 441 young women indicated not using contraceptives because they (currently) did not have sexual intercourse with a male partner, resulting in 11,227 young women included in this study. Of these young women, 1223 participated in 2005, 2726 in 2012, and 7278 in 2017.

Characteristics of the study population
The young women in our final sample had a median age of 20 years (interquartile range (IQR) 18-23 years). In 2017, less participants were aged ≤ 18 years and more participants were aged ≥ 22 years (Table 1). These age differences can be ascribed to an increasing age of first sexual intercourse (and hence sexually experienced individuals) in the Netherlands (De Graaf, de Ter Schure, & de Van Liere, 2020). There is a small shift towards a higher educational level (from 34 to 45% more educated young women), which resembles changes in the general population (Dutch Bureau of Statistics). Significant differences over the years were found in all demographic characteristics; however, this was often caused by the large sample size resulting in significant but small absolute differences, except for educational level.

Trends in types of contraceptive used over time
Contraception use was high among participants. In total, the most frequently used contraceptive method was oral contraceptives. We assessed trends over time for contraceptive methods used by more than 5% of young women in at least one inclusion year. The overall proportion of young women using oral contraceptive decreased significantly (P < 0.001), with a specific decrease between 2012 and 2017 from 64 to 53%, respectively. Another significant trend over time was seen for intrauterine device (IUD) use, which increased between 2005 and 2017 from 3 to 13%, respectively (P < 0.001). There was a slight increase in condom use over time, from 6 to 8% (P = 0.009). No *Girls who indicated they did not use contraceptives because they currently do not have sexual contact are excluded from analyses **Including the following: Hiduism, Judaism, Buddhism, Sikhism, Ásatrú, Mandaeism, Paganism, apostolic society, Bahá'í, ietsism/somethingism, native Indian religion, nature religions, Wicca, Yezidi, and Winti #Educational level was dichotomized. Higher general secondary education, pre-university education, higher vocational education, and university were classified as more educated, and all other categories as less educated ##Weighted percentage trends were seen for the combined use of condoms and oral contraceptives and for no contraceptive use (Table 2). Overall, no contraceptive use is stable over time (P = 0.4), while SARC use decreases significantly (P < 0.001) and LARC use increases significantly (P < 0.001) (Fig. 1). These trends were also found when controlling for demographic factors (age, religion, educational level, ethnicity, and partner status) (Supplementary Table 1).
Stratified by age, only among ≤ 18 years old young women, a significantly decreasing trend in no contraceptive use was seen (P < 0.01). SARC use significantly decreased over time for all age groups, except for the youngest age group (all P < 0.001). On the other hand, LARC use significantly increased over time for all age groups (all P < 0.001) (Fig. 2). Trends did not differ significantly by age group (P = 0.17).
By religion, neither decreasing nor increasing trends were seen in no contraceptive use. For SARC use, significantly decreasing trends were seen among non-religious young women (P < 0.001), and young Christian women who indicate their religion is of some importance to them (P < 0.001). LARC use showed significantly increasing trends over time among for the same subgroups (both P < 0.001). For all other religions, young Christian women to whom religion is very important, young Muslim women, and young women of other religions-no significant trends were seen in SARC and LARC use (Fig. 3). Trends differed significantly by religion (P = 0.02).
No significant changes in no contraceptive use were seen over the years for both educational level groups, while SARC use significantly decreased over the years among both less and more educated young women (both P < 0.001). LARC use is significantly increasing among both groups (both P < 0.001), but seems to be increasing more among more educated young women, since trends significantly differed by educational level (P = 0.01) (Fig. 4).
Stratifying by ethnicity, no contraceptive use remained stable for all groups (Dutch/ Western, Turkish/Moroccan, Surinamese/Antillean, other non-Western). SARC use significantly decreased among Dutch/Western (P < 0.001), Turkish/Moroccan (P < 0.01) and Surinamese/Antillean young women (P < 0.01), but no significant change over time was seen among other non-Western young women. LARC use significantly *Girls who indicated they did not use contraceptives because they currently do not have sexual contact are excluded from analyses increased only among Dutch/Western young women (P < 0.001). Possibly partly due to the small cell counts, increases in LARC use among Turkish/Moroccan, Surinamese/ Antillean, and other non-Western young women were non-significant. Overall trends neither differed significantly by ethnic group (P = 0.06) (Fig. 5). SARC and LARC use did not seem to differ between single young women and women in a relationship. In both groups, SARC use significantly decreased, while LARC use significantly increased. There was no significant interaction between relationship status and year of inclusion, so these trends were the same for young women in and outside a relationship (P = .152) (Fig. 6).

Discussion
We assessed trends in types of contraceptives used, in long-acting reversible contraceptive (LARC) use and in short-acting reversible contraceptive (SARC) use over a period of 12 years by demographic factors among young women aged 12 to 25 years, with experience of sexual intercourse in the Netherlands. Overall, SARC use was decreasing while LARC use was increasing. The decrease in SARC use could be mainly attributed to a decrease in oral contraceptive use, while a significant increase in the use of intrauterine devices could account for the rise in LARC use. This increase in LARC use confirms what was found in several earlier (mainly USA, but also French, UK, and sub-Saharan African) studies (Adedini et al., 2019;Connolly et al., 2014;Eisenberg, Allsworth, Zhao, & Peipert, 2012;Kavanaugh & Jerman, 2018;Law et al., 2016;Moreau et al., 2013;Pazol et al., 2016;Walsh-Buhi & Helmy, 2018;Whitaker, Sisco, Tomlinson, Dude, & Martins, 2013). However, the specific type of LARC that is increasingly used varies per study. The National Survey of Family Growth for example, found that the increase in LARC use was driven by an increase in IUD, whereas in a study among US college students, this trend was driven by implant use. Irrespective of the specific method that drives the trend, LARC use can be considered beneficial for women. LARC is, once inserted, independent of user compliance and found to be very effective for pregnancy prevention (Polis et al., 2016;Shoupe, 2016;Stoddard et al., 2011). An increase in its use might therefore eventually lead to a decrease in unwanted pregnancies and abortions (Biggs, Rocca, Brindis, Hirsch, & Grossman, 2015;Hubacher, Spector, Monteith, Chen, & Hart, 2017).
Compared to the increase in LARC use, the decrease in SARC was less often confirmed in the literature. Among young women aged 12 to 16 years in the Netherlands, oral contraceptive use seems to be rather stable between 2001 and 2017 (Stevens et al., 2018). This trend is also stable among women aged 16-44 in Ireland between 2008(O'Mahony, Liddy, Barry, & Bennett, 2015, as well as among women aged 15-44 years in the USA between 2008 and 2014 (Kavanaugh & Jerman, 2018). The use of other types of SARC (patch, vaginal ring, and injectable contraceptives) slightly declined in the USA from 8 to 7% between 2011 and 2014 (Walsh-Buhi & Helmy, 2018). These results suggest that in some other countries, the increase in LARC use results in Fig. 3 trends over time in contraceptive use by religion. Trends differed significantly by religion group (p=.024). # Numbers in some groups are small, explaining the large proportional differences tha show no statistically significant trend. Significance indicated; ** p<0.01, *** p<0.001 an increase in the use of modern contraceptives in general, whereas in the Netherlands, the increase in LARC use almost equals the decrease in SARC use.
The increasing trend in LARC use combined with the decreasing trend in SARC use and stable trends in no contraceptive use suggests that at least part of the young women in the Netherlands with experience of contraceptive use switch contraceptive method. Switching from SARC to LARC has been shown in the National Survey of Family Growth in which women aged 15-44 years who were not satisfied with their hormonal SARC were twice as likely to currently use LARC (Kavanaugh,Jerman,& Fig. 4 Trends over time in contraceptive use by educational level. Trends differed significantly by education group (p=.010). Significance indicated; ** p<0.01, *** p<0.001 Finer, 2015). Also, Law et al. (2016) found women aged 15-44 years switching towards LARC methods between 1999 and 2014. Additionally, more younger women, thus new users, started using LARC. This might be caused by availability of more diverse and newer LARC methods. Accessibility to LARC methods, either through online information or personal information by physicians, might also influence the increase in LARC uptake. Hubacher and colleagues (2017) studied LARC acceptance among young women aged 18-29 years who visited health centers with a request for oral or injectable contraceptives. Participants were randomized to get either SARC or LARC. Among these initially SARC-preferring participants, LARC use was found to be highly acceptable, with a probability of method continuation of 78% vs. 53% in the randomized SARC group. The Dutch College of General Practitioners accepted a new standard for contraception in 2011. One of the core guidelines in this standard is to give information about a broad array of contraceptive methods, to enable people to make wellinformed personal choices. This might partly explain the gradual diversification in contraceptive choices of young women in the Netherlands. Not all demographic groups shift towards LARC use equally. A closer look at various demographic groups revealed interesting differences in these trends. For young women ≤ 18 years, the increase in LARC use coincided with a decrease in no contraceptive use, which is a positive finding in terms of pregnancy prevention. For Turkish/Moroccan and Surinamese/Antillean young women, there was a significant decrease in SARC use, but there were no significant trends for either no contraceptive use or LARC use. It seems that part of these young women shifted to no contraceptive use and part to LARC use, which suggests an increase in risk for some of the young women with these immigrant backgrounds. Trends significantly differed by religion and educational level. SARC use decreased and LARC use increased only among young non-religious women and young Christian women for whom religion is of some importance, not among other religious subgroups. LARC use also seemed to increase stronger among more educated young women compared to less educated young women. These findings add to the literature, since these trends are rarely studied and if studied, trends were similar in all age, ethnic, and education groups (Adedini et al., 2019;Kavanaugh & Jerman, 2018). This study was also the first to differentiate trends in contraceptive use by the importance of religion among Christian young women.
This study has several limitations. First, we were unable to assess some demographic factors for which trends might differ (e.g., income 20,27 , geographical residence 22,47 , or maternal educational level 49 ) because of the broad focus of the sex under the age of 25 studies. However, based on current literature, we were able to assess the most commonly found demographic factors influencing contraception use or choice. Second, we were unable to extensively assess motives and attitudes regarding contraceptive choices. From our perspective, it is important that women are able to choose the contraceptive method that fits their needs and expectations. Insight into motives and attitudes towards SARC and LARC as contraceptive methods enables more tailored advice on contraceptive methods. Our data also does not give insight in possible hormonal motives for the decrease in oral contraceptives, since in 2017 no distinction was made between hormonal and copper IDU and we did not assess other non-hormonal methods like periodic abstinence and withdrawal methods. Last, this study is not a longitudinal study, preventing insight into what proportion of increase in LARC is caused by a switch from SARC to LARC.
In conclusion, SARC use has decreased and LARC use has increased between 2005 and 2017 in the Netherland among young women aged 12-25 years who experienced sexual intercourse at least once. Since the vast majority of Dutch young women used oral contraceptives for the past decades, these trends might eventually lead to a further decrease in unwanted pregnancies and abortions. These trends in SARC use and LARC use were absent or less steep among young Christian women for whom religion is very important, young Muslim women, young women with other religions, and less educated young women.
To avoid unplanned pregnancies, it is important that (young) women use the kind of contraceptive that fits their personal situation best. If a contraceptive method fits the needs and requirements of a woman, she is more likely to use this method more consistently and correctly. This results in better protection against unplanned and potentially unwanted pregnancy and less abortion (Sridhar, Rodriguez, Roque, & Abutouk, 2016). It is therefore important that healthcare professionals, sexuality education, as well as online platforms inform about a broad range of contraceptive methods. Furthermore, preventive efforts should focus especially on those groups that lag behind in the shift towards LARC, i.e., religious and lower educated young women.
Additional file 1: Table S1. Multivariable multinomial logistic regression of the association between year of inclusion and contraceptive use corrected for demographic factors*.